Sodium citrate is an anticoagulant that is commonly used in blood collection for hemostatic testing. It inhibits the coagulation cascade, preventing the formation of fibrin clots. Sodium citrate tubes are designed to collect blood specimens intended for specific coagulation tests, such as prothrombin time (PT) and activated partial thromboplastin time (APTT).
This article provides a comprehensive overview of sodium citrate tubes, addressing their mechanism of action, indications, collection procedures, precautions, and quality control measures.
Sodium citrate acts as an anticoagulant by chelating calcium ions, which are essential for the activation of the coagulation cascade. The chelation of calcium prevents the conversion of prothrombin to thrombin, thereby inhibiting the formation of fibrin clots.
Sodium citrate tubes are indicated for the collection of blood specimens for the following coagulation tests:
Step-by-Step Approach to Sodium Citrate Tube Collection:
Follow these precautions when using sodium citrate tubes:
Quality control measures are essential to ensure the accuracy and reliability of sodium citrate tube-based coagulation testing:
Common problems encountered with sodium citrate tubes and their solutions:
Problem | Solution |
---|---|
Clotted specimen | Recollect the specimen using a new tube and mix thoroughly immediately after collection. |
Hemolyzed specimen | Handle the specimen gently and avoid prolonged tourniquet application. |
Short tube fill | Collect an additional specimen in a new tube and ensure the correct fill level. |
Prolonged centrifuge time | Ensure the centrifuge is operating at the correct speed and时间. |
Sodium citrate tubes are essential tools for accurate and reliable hemostasis testing. By adhering to proper collection procedures, observing precautions, implementing quality control measures, and following effective strategies, laboratories can ensure the integrity of sodium citrate tube-based coagulation testing. This contributes to the provision of accurate and timely diagnostic information for patient care.
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